Do Accutane and alcohol mix or is it dangerous?

I've been told by my dermatologist that in no case must I drink alcohol, even in moderate quantities, since I'm currently taking Accutane (isotretinoin). I'm a moderate, casual drinker in normal circumstances (2-5 drinks per week) so abstinence hasn't been a real issue so far and I've never had any issues with my liver, but I've been reading online that a few drinks every now and then while taking Accutane isn't such a big deal. With the holidays coming up, I'm wondering how bad it can be if I have a glass of wine over dinner? My family will definitely notice if I'm not drinking and I don't want to have to explain everything.

You should not be drinking and taking Accutane. This is a big no no. It may not kill you, but it's not a smart idea. 

As a person who has tried both Accutane and Proactiv, you can't compare the two. For me, Proactiv didn't work any better than any other Benzoyl Peroxide-based acne treatment that you could buy at your local CVS or Walgreens. Proactiv is just a well-marketed toner, cleanser and moisturizer. They give each of their lotions fancy names, but at the end of the day, you could buy any of these products at your local drugstore. When you buy Proactiv, 90% of what you're paying goes towards all of the marketing you're seeing. Proactiv might help with very mild acne that would disappear on its own eventually. Accutane works for chronic mild to severe acne that won't go away. In my opinion, Accutane is a cure and Proactiv is a mild treatment (if you can even call it that). 

It is not wise to drink alcohol while you're on Accutane. As the users below have stated, both alcohol and Accutane are processed in your liver. Your liver is a very important organ and you do not want to damage it. Why take the risk?