Rub a cream on your face every day, and your wrinkles will miraculously disappear. At least, that’s what we’d all love to do.

The unfortunate truth is that the anti-aging effects of most skin care products aren’t supported by hard evidence.

We discussed this with Dr. Stefani T. Kappel, a board-certified dermatologist based in Newport Beach, CA.

“Just because a cream feels nice or smells good doesn’t mean it will work,” she told us. “For example, vitamin C has been getting a great deal of attention lately. However, some formulations of vitamin C break down and are inactive before even penetrating the skin.”

Her advice: “If you want to improve the quality of your skin and decrease wrinkles, it’s important to invest in ‘smart’ products that really work and give results, and not waste your money on a cream that has a fancy bottle with curb appeal.”

Enter Retin-A, a topical product that is backed by scientific data.

What is Retin-A, and how does it work?

Retin-A, also known as tretinoin or retinoic acid, is a naturally occurring, acidic form of vitamin A. It’s part of a large class of chemical compounds called retinoids, which are used in medicine to regulate cell growth.

Of the many retinoids on the market, both natural and synthetic, Retin-A is the most commonly recommended by dermatologists for the treatment of acne, wrinkles, and skin damage. This is likely due to the fact that it is the most potent, and that its effects are well documented.

UV radiation is one of the major contributing factors to accelerated skin aging. This is known as photo damage or photoaging. As there is substantial scientific evidence to support its effectiveness, Retin-A is approved by the FDA for the clinical treatment of photodamaged skin.

“Tretinoin is very effective in reversing the photo damage that has already occurred, and also in protecting against future damage,” says Kappel. “It also helps in the prevention of skin cancer and pre-cancers.”

Retin-A is available in three different prescription strengths, 0.025%, 0.05%, and 0.1%, and can be purchased as a cream, gel, or micro-emulsion.

“There are also oral forms of retinoids used in medicine and dermatology, such as isotretinoin and acitretin,” says Kappel. “Although the mechanism in which tretinoin works is not clearly defined, we do know that it affects the keratinocytes and fibroblasts at a cellular level. This keeps them healthy, productive, and helps stimulate collagen production.”

Along with sun damage, Retin-A is also commonly used to treat age spots, acne, and wrinkles.

“For acne, it prevents the epithelial cells from sticking together in the hair follicle, which opens the pores and prevents breakouts,” says Kappel. “In terms of anti-aging properties, the stimulation of collagen and the regulation of the cell cycle help improve skin texture.”

How is Retin-A effective for wrinkles?

If you look at a child’s skin, you’ll see that it’s smooth and tight, without visible pores or wrinkles.

“This is because children have a faster transepidermal time, which is the time it takes for new skin cells to make their way from the bottom layer of the epidermis to the top,” Kappel explains. “Once they get to the top, they are sloughed off.”

Retin-A works by stimulating the production of collagen, increasing cell turnover and regulating the cell cycle.

“As we age, our skin cells become less active — they get sleepy,” says Kappel. “That’s why children have vibrant, healthy-appearing skin, while adult skin has a dull appearance. Tretinoin speeds up cell turnover and stimulates collagen, which kids have a ton of. This reduces fine lines and wrinkles.”

What are the potential side effects of Retin-A?

According to Kappel, Retin-A can make the skin thinner for some, although this generally occurs following improper use. People with thin skin should use Retin-A less frequently, and combine it with creams that hydrate and strengthen the skin barrier.

Initially, most people will experience irritation, redness, dryness, and peeling. These side effects appear within five days and last anywhere from two to six weeks.

If your wrinkles appear worse at first, don’t panic — this is normal. By gradually introducing tretinoin into your skincare routine, these side effects will eventually dissipate.

How can I introduce Retin-A into my skincare routine?

“I often recommend that patients start off slowly,” says Kappel. “Use the cream or gel once or twice per week, and increase the frequency every two to three weeks until you work your way up to nightly use.”

Before application, wash your skin. Wait 15 minutes, and apply the cream or gel once your face has completed dried off.

“Use a pea-sized amount and dab it onto your forehead, cheeks and chin, Then ‘connect the dots’ by lightly spreading the cream to the entire face using an upward motion,” says Kappel.

Don’t rub it in too aggressively — a light application is all that’s needed for it to penetrate into the skin. Make sure to take extra caution around your eyes and mouth.

If you find the irritation too much to bear in the beginning, Kappel suggests mixing the tretinoin with one pump of moisturizer in the palm of your hand. This will decrease irritation without interfering with the product’s effectiveness.

It is also recommended to use tretinoin only at night, as it breaks down in the sunlight.

Improvements in skin quality from a standard application of 0.05% tretinoin cream can be seen after six to 12 weeks. With continued treatment for 12 months or more, new collagen formation and elastin production will start to become increasingly visible.

How does Retin-A compare to other wrinkle treatments?

“There are other ways to achieve similar goals — chemical peels and laser resurfacing, for instance. However, topical retinoids have the most scientific data supporting beneficial anti-aging effects,” says Kappel.

Split-face comparisons of procedures were performed in a study published in the Annals of Dermatology. Researchers evaluated the effectiveness of tretinoin when compared to intense pulsed light (IPL) and nonablative laser treatments in 19 women aged between 30 and 52 years of age.

The results:

  • IPL decreased wrinkles by 20.4%, whereas the application of 0.1% tretinoin cream decreased wrinkles by 21%
  • Laser decreased wrinkles by 20%, whereas 0.1% tretinoin cream decreased wrinkles by 26.8%

At the end of the study, the researchers concluded that there was no significant difference between the treatments in the degree of overall wrinkle improvement.

As the cream is less invasive and more convenient, it may therefore be a preferred option for wrinkle treatment and prevention.

According to a study published by the University of Michigan Health Systems, using Retin-A for one to three months prior to a chemical peel, laser treatment, or dermabrasion will cause the skin to heal faster.

This would mean that tretinoin can play a role in enhancing the results and efficiency of non-invasive skin rejuvenation procedures. However, Kappel recommends that you wait for one week after these procedures before resuming your Retin-A regimen.

The experts have spoken: if you’re looking for a skincare product that has scientifically proven benefits, Retin-A is the answer. “It’s definitely a favorite among dermatologists to slow down the aging process and minimize fine lines and wrinkles,” concludes Kappel.

Updated, November 2017

About The Author

Articles by

Jedha Dening is a contributing health and beauty writer for Zwivel. She specializes in crafting compelling words for B2B & B2C health companies and publications worldwide.

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