Has hyaluronidase been approved by the FDA yet?

My sister is planning on going to see a specialist about getting some of her wrinkles cleared up with dermal fillers. She's heard about bad experiences people have apparently had with some fillers and is now having second thoughts about doing it. She says her doctor has promised her that there is very little that could possibly go wrong and if there were any negative effects he could give her a drug called hyaluronidase that would reverse the effects of the filler. That put her at ease until she learned that hyaluronidase hasn't been approved by the FDA. But is that really true? And if it hasn't been already, wouldn't it just be a matter of time? I have trouble imagining a doctor administering something potentially harmful to one of their patients.


F, 45, Kentucky

Hyaluronic Acid dermal fillers are naturally biodegradable because hyaluronic acid is a natural substance in the tissue of the skin. The results of hyaluronic acid cosmetic filler, such as Restylane®, Juvederm® Ultra Plus® and Restylane Lyft® are also quickly dissolvable with hyaluronidase if you don't like the results. 

The FDA has approved Hylenex® and Vitrase®, which have a Hyaluronidase base, for the absorption and dispersion of injectables. Hyaluronidase speeds up the body's natural dissolving process and more quickly dissolves hyaluronic acid fillers. Any filler regrets can be safely addressed with hyaluronidase. 

When I looked it up, it appears that there are several drugs that include hyaluronidase that have been approved by the FDA. As for what those drugs are or how they are typically used, I'm not sure. I would definitely suggest asking your doctor if you are wondering about FDA approval. Sometimes the approval is not actually all that important.