How do I test for allergic reactions to Juvederm?

I've been toying for a while with the idea of enhancing the volume of my lips, and after all this research I've decided that Juvederm is my first option. The only thing is I have a history of allergies, it runs in the family, and Juvederm could constitute a potential threat to me. How can I find out if I'm allergic to Juvederm or not?


F, 39, New Hampshire

Juvederm is an excellent dermal filler often used on the nasolabial folds, lips, tear-troughs, cheeks and jawline. I would encourage you, however, to leave the choice of dermal filler to your dermatologist or plastic surgeon. This decision depends on the specific presentation and judgment and experience of your dermatologist.

While mild inflammatory reactions and bruising are common with Juvederm, it is very rare to experience severe reactions or an allergic response to hyaluronic acid dermal fillers. Hypersensitivity reactions, which are sometimes seen with other types of fillers, are exceedingly rare with hyaluronic acid. Common side effects include swelling and redness at the injection site. To reduce the pain associated with the injections, your dermatologist may use a topical anesthetic or lidocaine.

Without a personal consultation I can't speak to your prior history or family history of allergies, but I would be surprised if those allergies would be due to hyaluronic acid.

The FDA does recommend preliminary allergic testing on fillers with animal-based materials like collagen, but the hyaluronic acid in HA fillers is typically synthesized from non-animal sources.

Also, please keep in mind that Juvederm filler injections, like all hyaluronic acid lip fillers, can also be "undone" with a subsequent injection of hyaluronidase. In rare reported cases where there have been adverse reactions to injections of hyaluronic acid-based dermal fillers, these reactions ceased following an injection of hyaluronidase.

Always choose a board-certified plastic surgeon or dermatologist for the best results.

Dr. Robert N. Young has 3 Filler to lip lines before & afters:

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The primary ingredient in Juvederm is hyaluronic acid, which is naturally produced by the body. While it's common to experience side effects like redness, bruising, swelling and a small amount of pain following juvederm injections, it's very rare to experience an allergic response or any serious adverse reactions.

We normally test for allergic reactions to collagen-based injectable fillers because allergic reactions to collagen are more the norm. But because the incidence of allergic reaction to hyaluronic acid fillers is extremely rare, it is not our practice to perform an allergy test prior to treatment.

You may request a "test spot" from your dermatologist if you have valid concerns about a reaction to Juvederm. Testing for adverse effects with injectable hyaluronic acid will require you to purchase a syringe. Your doctor can test the injection on your forearm. If no adverse effects are visible within 48 hours, the same syringe can still be used. In the event of an adverse event, you would still be financially responsible for it.

I should stress that preliminary allergy testing with Juvederm, Juvederm Ultra and Juvederm Ultra Plus is typically not required.

Dr. Lawrence Broder has 1 Fillers, Laser Resurfacing before & after:

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You could have a very small amount pre-injected at a remote site in your body as a test spot to determine if you have an allergy. For your comfort hyaluronic acid fillers are almost completely inert substances and I have not yet seen an allergy to the products. Good Luck!

Allergic reactions are relatively rare with hyaluronic acid fillers since HA is a naturally occurring substance in our own tissues. However, you, as others have suggested, could purchase a single syringe and test it in a nonfacial area and if no reaction occurs within a few days, go back to the surgeon to have the stored syringe used for its primary purpose. This kind of skin testing is more commonly required with collagen-based products than the new generation of HA fillers. In my own practice I have never skin tested anyone for Juvederm reactions and have not had issues. Good luck!

Pay for full syringe($600+++) and have a drop placed subdermally in dorsum of hand . If no reaction after 2 days than you should be good to go. If you have allergic reaction, which is very unlikely, than you lost the costs of the one full syringe. Risk reward concept....

Dr. Darryl Blinski has 1 Restylane before & after:

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Juvederm is a class of dermal fillers that is an HA (hylaronic acid)  that is naturally occurring in your body. allergic reactions are very rare. However, there are preservatives that could be an issue so you can do a skin test with a small amount. I would recommend seeing your allergist first to discuss if your allergies are severe. 

Dr. Jack Peterson has 1 Fillers before & after:

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